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Specifically, 15 proteins were upregulated in the HACE group, including Ribokinase (RBKS), Protein Transport Factor (PRTFDC1), Fc Receptor-Like Protein 6 (FCRL6), C-C Motif Chemokine Ligand 27 (CCL27), Cathepsin S (CTSS), Defensin Beta 4 A (DEFB4A), Interleukin-1 Receptor-Associated Kinase 4 (IRAK4), Tenascin-R (TN-R), Corneodesmosin (CDSN), SPARC-related Modular Calcium-Binding Protein 2 (SMOC2), Ezrin (EZR), Galectin-8 (gal-8), A Disintegrin and Metalloproteinase 15 (ADAM15), and FK506 Binding Protein 7 (FKBP7)
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Dual and multi-receptor obesity peptide comparison (June 2026) Peptide Survodutide (BI 456906) Receptor targets GLP-1 + Glucagon Top reported weight loss 16.6% (Phase 3 SYNCHRONIZE-1, 76 weeks) Route Subcutaneous, once weekly FDA status Investigational Peptide Retatrutide Receptor targets GLP-1 + GIP + Glucagon (triple) Top reported weight loss 24.2% (Phase 2, 48 weeks) Route Subcutaneous, once weekly FDA status Investigational Peptide Tirzepatide (Mounjaro / Zepbound) Receptor targets GLP-1 + GIP Top reported weight loss 20.9% (SURMOUNT-1, 72 weeks) Route Subcutaneous, once weekly FDA status FDA-approved (T2D and obesity) Peptide Semaglutide (Ozempic / Wegovy / Rybelsus) Receptor targets GLP-1 only Top reported weight loss 14.9% (STEP 1, 68 weeks) Route Subcutaneous, once weekly (oral Rybelsus daily) FDA status FDA-approved (T2D and obesity) Peptide CagriSema (cagrilintide + semaglutide) Receptor targets GLP-1 + Amylin Top reported weight loss 22.7% (REDEFINE-1 Phase 3) Route Subcutaneous, once weekly FDA status Investigational Numbers are from each peptide's primary trial
